Meiotic Origins of Maternal Age-Related Aneuploidy

被引：147
作者：
Chiang, Teresa [1 ]
Schultz, Richard M. [1 ]
Lampson, Michael A. [1 ]
机构：
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
BIOLOGY OF REPRODUCTION | 2012年 / 86卷 / 01期
基金：
美国国家卫生研究院;
关键词：
aging; aneuploidy; female infertility; meiosis; oocyte; SPINDLE ASSEMBLY CHECKPOINT; REDUCTIONAL CHROMOSOME SEGREGATION; IN-VITRO FERTILIZATION; MOUSE MEIOSIS I; DOWN-SYNDROME; HUMAN OOCYTES; SISTER CHROMATIDS; DNA-REPLICATION; X-CHROMOSOME; FEMALE MICE;
D O I：
10.1095/biolreprod.111.094367
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chromosome segregation errors in female meiosis lead to aneuploidy in the resulting egg and embryo, making them one of the leading genetic causes of spontaneous abortions and developmental disabilities in humans. It is known that aneuploidy of meiotic origin increases dramatically as women age, and current evidence suggests that most errors occur in meiosis I. Several hypotheses regarding the cause of maternal age-related aneuploidy have been proposed, including recombination errors in early meiosis, a defective spindle assembly checkpoint in meiosis I, and deterioration of sister chromatid cohesion with age. This review discusses findings in each area, and focuses especially on recent studies suggesting that deterioration of cohesion with increasing maternal age is a leading cause of age-related aneuploidy.
引用
收藏
页数：7
相关论文
共 83 条
[1]   Maternal age and risk for trisomy 21 assessed by the origin of chromosome nondisjunction: a report from the Atlanta and National Down Syndrome Projects [J].
Allen, Emily Graves ;
Freeman, Sallie B. ;
Druschel, Charlotte ;
Hobbs, Charlotte A. ;
O'Leary, Leslie A. ;
Romitti, Paul A. ;
Royle, Marjorie H. ;
Torfs, Claudine P. ;
Sherman, Stephanie L. .
HUMAN GENETICS, 2009, 125 (01) :41-52
[2]   First-meiotic-division nondisjunction in human oocytes [J].
Angell, R .
AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (01) :23-32
[3]  
Battaglia DE, 1996, HUM REPROD, V11, P2217
[4]   Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase [J].
Brunet, S ;
Maria, AS ;
Guillaud, P ;
Dujardin, D ;
Kubiak, JZ ;
Maro, B .
JOURNAL OF CELL BIOLOGY, 1999, 146 (01) :1-11
[5]   Functionality of the spindle checkpoint during the first meiotic division of mammalian oocytes [J].
Brunet, S ;
Pahlavan, G ;
Taylor, S ;
Maro, B .
REPRODUCTION, 2003, 126 (04) :443-450
[6]   Non-disjunction of chromosome 18 [J].
Bugge, M ;
Collins, A ;
Petersen, MB ;
Fisher, J ;
Brandt, C ;
Hertz, JM ;
Tranebjærg, L ;
de Lozier-Blanchet, C ;
Nicolaides, P ;
Brondum-Nielsen, K ;
Morton, N ;
Mikkelsen, M .
HUMAN MOLECULAR GENETICS, 1998, 7 (04) :661-669
[7]   AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis [J].
Chelysheva, L ;
Diallo, S ;
Vezon, D ;
Gendrot, G ;
Vrielynck, N ;
Belcram, K ;
Rocques, N ;
Márquez-Lema, A ;
Bhatt, AM ;
Horlow, C ;
Mercier, R ;
Mézard, C ;
Grelon, M .
JOURNAL OF CELL SCIENCE, 2005, 118 (20) :4621-4632
[8]   Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes [J].
Chiang, Teresa ;
Schultz, Richard M. ;
Lampson, Michael A. .
BIOLOGY OF REPRODUCTION, 2011, 85 (06) :1279-1283
[9]   Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes [J].
Chiang, Teresa ;
Duncan, Francesca E. ;
Schindler, Karen ;
Schultz, Richard M. ;
Lampson, Michael A. .
CURRENT BIOLOGY, 2010, 20 (17) :1522-1528
[10]   Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs [J].
Duncan, Francesca E. ;
Chiang, Teresa ;
Schultz, Richard M. ;
Lampson, Michael A. .
BIOLOGY OF REPRODUCTION, 2009, 81 (04) :768-776
123456789