Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors

被引：12

作者：

Khazamipour, Nastaran ^{[1
,2
]}

Al-Nakouzi, Nader ^{[1
,2
]}

Oo, Htoo Zarni ^{[1
,2
]}

Orum-Madsen, Maj ^{[1
,2
]}

Steino, Anne ^{[2
,3
]}

Sorensen, Poul H. ^{[3
,4
]}

Daugaard, Mads ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Urol Sci, Vancouver, BC V5Z 1M9, Canada

[2] Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

[4] British Columbia Canc Res Ctr, Dept Mol Oncol, Vancouver, BC V5Z 1L3, Canada

来源：

CELLS | 2020年 / 9卷 / 04期

关键词：

oncofetal chondroitin sulfate; chondroitin sulfate; cancer; solid tumors; target; pediatric cancer; VAR2; LAMININ RECEPTOR PROTEIN; GROWTH-FACTOR RECEPTOR; ANTIGEN; 5T4; TROVAX; CANCER PATIENTS; HUMAN-PLACENTA; MYC ONCOGENE; GLYCOSAMINOGLYCAN BINDING; TROPHOBLAST PROLIFERATION; PLASMODIUM-FALCIPARUM; PERICELLULAR MATRIX;

D O I：

10.3390/cells9040818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Solid tumors remain a major challenge for targeted therapeutic intervention strategies such as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid tumor targets have to comply with the key biological requirement of being differentially over-expressed in solid tumors and metastasis, in contrast to healthy organs. Oncofetal chondroitin sulfate is a cancer-specific secondary glycosaminoglycan modification to proteoglycans expressed in a variety of solid tumors and metastasis. Normally, this modification is found to be exclusively expressed in the placenta, where it is thought to facilitate normal placental implantation during pregnancy. Informed by this biology, oncofetal chondroitin sulfate is currently under investigation as a broad and specific target in solid tumors. Here, we discuss oncofetal chondroitin sulfate as a potential therapeutic target in childhood solid tumors in the context of current knowhow obtained over the past five years in adult cancers.

引用

页数：12

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