Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach

被引：9

作者：

Devpura, Suneetha ^{[1
]}

Pattamadilok, Bensachee ^{[2
]}

Syed, Zain U. ^{[2
]}

Vemulapalli, Pranita ^{[2
]}

Henderson, Marsha ^{[2
]}

Rehse, Steven J. ^{[3
]}

Hamzavi, Iltefat ^{[2
]}

Lim, Henry W. ^{[2
]}

Naik, Ratna ^{[1
]}

机构：

[1] Wayne State Univ, Dept Phys & Astron, Detroit, MI 48201 USA

[2] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI 48202 USA

[3] Univ Windsor, Dept Phys, Windsor, ON N9B 3P4, Canada

来源：

BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 06期

关键词：

SKIN; PIGMENTATION; OBESITY;

D O I：

10.1364/BOE.2.001664

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements. (C)2011 Optical Society of America

引用

页码：1664 / 1673

页数：10

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