Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis

被引：68

作者：

Fan, Yao-Yue ^{[1
]}

Xu, Jin-Biao ^{[1
]}

Liu, Hong-Chun ^{[1
]}

Gan, Li-She ^{[2
]}

Ding, Jian ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China

[2] Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 12期

关键词：

NATURAL-PRODUCTS; FORTUNEI; ASSAY;

D O I：

10.1021/acs.jnatprod.7b00412

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new cephalotane-type diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated and characterized from Cephalotaxus sinensis. Compounds 1-3 represent the first examples of A-ring-contracted cephalotane-type dinorditerpenoids, and compound 4 is an A-ring-contracted norditerpenoid. The biosynthetic pathways for compounds 1-4 are postulated with the coexisting cephalotane-type troponoids as the precursors. Compounds 11 and 12 showed significant cytotoxicities against a panel of tumor cell lines (A549, KB, HL-60, and HT-29) with IC50 values ranging from 0.464 to 6.093 mu M.

引用

页码：3160 / 3167

页数：8

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