New horizons for imaging lymphatic function

被引:99
作者
Sharma, Ruchi [1 ]
Wendt, Juliet A. [1 ]
Rasmussen, John C. [1 ]
Adams, Kristen E. [1 ]
Marshall, Milton V. [1 ]
Sevick-Muraca, Eva M. [1 ]
机构
[1] Baylor Coll Med, Div Mol Imaging, Dept Radiol, Houston, TX 77030 USA
来源
LYMPHATIC CONTINUUM REVISITED | 2008年 / 1131卷
关键词
lymph flow; NIR optical imaging; fluorescence; indocyanine green;
D O I
10.1196/annals.1413.002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this review, we provide a comprehensive summary of noninvasive imaging modalities used clinically for the diagnosis of lymphatic diseases, new imaging agents for assessing lymphatic architecture and cancer status of lymph nodes, and emerging near-infrared (NIR) fluorescent optical imaging technologies and agents for functional lymphatic imaging. Given the promise of NIR optical imaging, we provide example results of functional. lymphatic imaging in mice, swine, and humans, showing the ability of this technology to quantify lymph velocity and frequencies of propulsion resulting from the contractility of lymphatic structures.
引用
收藏
页码:13 / 36
页数:24
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