The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains

被引：57
作者：
Oka, A
Takashima, S
机构：
[1] Tottori Univ, Fac Med, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 6838504, Japan
[2] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Kodaira, Tokyo 187, Japan
来源：
ACTA NEUROPATHOLOGICA | 1999年 / 97卷 / 03期
关键词：
Down's syndrome; metabotropic glutamate receptor; mGluR5; glutamate;
D O I：
10.1007/s004010050985
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We investigated the expression of metabotropic glutamate receptor 5 (mGluR5), a subtype of group I mGluRs, in the cerebral cortex of cases with Down's syndrome (DS), using immunohistochemistry and immunoblotting with this receptor. The up-regulation of mGluR5 was observed in DS by immunohistochemistry, and atrophic pyramidal neurons were immunolabelled in elderly DS cases. Western blotting confirmed the increased expression in DS brains. Since group I mGluR regulates the metabolism of amyloid precursor protein (APP) and accelerates its processing into non-amyloidogenic APP, the overexpression of mGluR5 may be related to the pathological state of APP metabolism in DS.
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收藏
页码：275 / 278
页数：4
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