In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(L-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres

被引：81
作者：
You, Y
Lee, SW
Youk, JH
Min, BM
Lee, SJ
Park, WH
机构：
[1] Chungnam Natl Univ, Dept Text Engn, Taejon 305764, South Korea
[2] Inha Univ, Div NanoSyst, Dept Adv Fibre Engn, Inchon 402751, South Korea
[3] Seoul Natl Univ, Coll Dent, Dept Oral Biochem, Seoul 110749, South Korea
[4] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
POLYMER DEGRADATION AND STABILITY | 2005年 / 90卷 / 03期
关键词：
poly(glycolic acid); poly(L-lactic acid); electrospinning; porous ultra-fine fibre; biodegradability;
D O I：
10.1016/j.polymdegradstab.2005.04.015
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(L-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1, 1, 1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：441 / 448
页数：8
相关论文
共 31 条
[1]   Biodegradation and biocompatibility of PLA and PLGA microspheres [J].
Anderson, JM ;
Shive, MS .
ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) :5-24
[2]  
Bognitzki M, 2000, ADV MATER, V12, P637, DOI 10.1002/(SICI)1521-4095(200005)12:9<637::AID-ADMA637>3.0.CO
[3]  
2-W
[4]  
Bognitzki M, 2001, ADV MATER, V13, P70, DOI 10.1002/1521-4095(200101)13:1<70::AID-ADMA70>3.0.CO
[5]  
2-H
[6]  
Caruso RA, 2001, ADV MATER, V13, P1577, DOI 10.1002/1521-4095(200110)13:20<1577::AID-ADMA1577>3.0.CO
[7]  
2-S
[8]   Preparation of porous ultra-fine fibres via selective thermal degradation of electrospun polyetherimide/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibres [J].
Han, SO ;
Son, WK ;
Cho, DW ;
Youk, JH ;
Park, WH .
POLYMER DEGRADATION AND STABILITY, 2004, 86 (02) :257-262
[9]   The preparation of PVA-Pt/TiO2 composite nanofiber aggregate and the photocatalytic degradation of solid-phase polyvinyl alcohol [J].
He, CH ;
Gong, J .
POLYMER DEGRADATION AND STABILITY, 2003, 81 (01) :117-124
[10]   Poly(p-xylylene) nanotubes by coating and removal of ultrathin polymer template fibers [J].
Hou, HQ ;
Jun, Z ;
Reuning, A ;
Schaper, A ;
Wendorff, JH ;
Greiner, A .
MACROMOLECULES, 2002, 35 (07) :2429-2431
1234