Gut Microbiota and Immune Responses

被引：14
|
作者：
Dong, Lijun [1 ,2 ]
Xie, Jingwen [2 ]
Wang, Youyi [2 ,3 ]
Zuo, Daming [3 ,4 ]
机构：
[1] Southern Med Univ, Affiliated Hosp 5, Guangzhou 510900, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Immunol, Guangzhou 510515, Peoples R China
[3] Southern Med Univ, Sch Lab Med & Biotechnol, Inst Mol Immunol, Guangzhou 510515, Peoples R China
[4] Southern Med Univ, Zhujiang Hosp, Microbiome Med Ctr, Guangzhou 510282, Peoples R China
来源：
GUT MICROBIOTA AND PATHOGENESIS OF ORGAN INJURY | 2020年 / 1238卷
关键词：
Gut microbiota; Immune system; T cells; B cells; Macrophage; REGULATORY T-CELLS; SEGMENTED FILAMENTOUS BACTERIA; GERM-FREE MICE; COMMENSAL BACTERIA; INFLAMMATORY RESPONSES; INTESTINAL MICROBIOTA; HELICOBACTER-PYLORI; DENDRITIC CELLS; COLON-CANCER; INDUCTION;
D O I：
10.1007/978-981-15-2385-4_10
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The gut microbiota consists of a dynamic multispecies community living within a particular niche in a mutual synergy with the host organism. Recent findings have revealed roles for the gut microbiota in the modulation of host immunity and the development and progression of immune-mediated diseases. Besides, growing evidence supports the concept that some metabolites mainly originated from gut microbiota are linked to the immune regulation implicated in systemic inflammatory and autoimmune disorders. In this chapter, we describe the recent advances in our understanding of how host-microbiota interactions shape the immune system, how they affect the pathogenesis of immune-associated diseases and the impact of these mechanisms in the efficacy of disease therapy.
引用
收藏
页码：165 / 193
页数：29
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