Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor-Positive and -Negative Breast Cancer: a Nested Case-Control Study

被引：107

作者：

James, Rebecca E. ^{[1
]}

Lukanova, Annekatrin ^{[1
]}

Dossus, Laure ^{[1
]}

Becker, Susen ^{[2
]}

Rinaldi, Sabina ^{[3
]}

Tjonneland, Anne ^{[5
]}

Olsen, Anja ^{[5
]}

Overvad, Kim ^{[6
]}

Mesrine, Sylvie ^{[7
,8
]}

Engel, Pierre ^{[7
,8
]}

Clavel-Chapelon, Francoise ^{[7
,8
]}

Chang-Claude, Jenny ^{[1
]}

Vrieling, Alina ^{[1
]}

Boeing, Heiner ^{[9
]}

Schuetze, Madlen ^{[9
]}

Trichopoulou, Antonia ^{[10
,11
]}

Lagiou, Pagona ^{[10
,13
]}

Trichopoulos, Dimitrios ^{[12
,13
]}

Palli, Domenico ^{[14
]}

Krogh, Vittorio ^{[15
]}

Panico, Salvatore ^{[16
]}

Tumino, Rosario ^{[17
,18
]}

Sacerdote, Carlotta ^{[19
,20
]}

Rodriguez, Laudina ^{[21
]}

Buckland, Genevieve ^{[22
]}

Sanchez, Maria-Jose ^{[23
]}

Amiano, Pilar ^{[25
]}

Ardanaz, Eva ^{[24
,26
]}

Bueno-de-Mesquita, Bas ^{[27
]}

Ros, Martine M. ^{[27
]}

van Gils, Carla H. ^{[28
]}

Peeters, Petra H. ^{[28
]}

Khaw, Kay-Tee ^{[29
]}

Wareham, Nick ^{[30
]}

Key, Timothy J. ^{[31
]}

Allen, Naomi E. ^{[31
]}

Romieu, Isabelle ^{[4
]}

Siddiq, Afshan ^{[32
]}

Cox, David ^{[32
]}

Riboli, Elio ^{[33
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[2] Univ Klinikum Leipzig, Inst Lab Med Klin Chem & Mol Diagnost, Leipzig, Germany

[3] Int Agcy Res Canc, Sect Nutr & Metab, Biomarkers Grp, F-69372 Lyon, France

[4] Int Agcy Res Canc, Sect Nutr & Metab, Nutr Epidemiol Grp, F-69372 Lyon, France

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[7] Inst Gustave Roussy, INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[8] Paris S Univ, UMRS 1018, Villejuif, France

[9] German Inst Human, Dept Epidemiol, Nuthetal, Germany

[10] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[11] Hellen Hlth Fdn, Athens, Greece

[12] Acad Athens, Bur Epidemiol Res, Athens, Greece

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[15] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[16] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[17] ASP 7 Ragusa, Civile MP Arezzo Hosp, Canc Registry, Turin, Italy

[18] ASP 7 Ragusa, Civile MP Arezzo Hosp, Histopathol Unit, Turin, Italy

[19] HuGeF Fdn, Turin, Italy

[20] CPO Piemonte, Turin, Italy

[21] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[22] IDIBELL, Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Catalan, Spain

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Barcelona, Spain

[25] Basque Govt, Inst Invest BioDonostia, Publ Hlth Div Gipuzkoa, Barcelona, Spain

[26] Navarre Publ Hlth Inst, Pamplona, Spain

[27] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[28] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[29] Univ Cambridge, Cambridge, England

[30] MRC Epidemiol Unit, Cambridge, England

[31] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[32] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London SW7 2AZ, England

[33] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London SW7 2AZ, England

来源：

CANCER PREVENTION RESEARCH | 2011年 / 4卷 / 10期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ESTROGEN-RECEPTOR; FREE TESTOSTERONE; WOMEN; ANDROGENS; THERAPY; METAANALYSIS; ENDOCRINE; VALIDITY;

D O I：

10.1158/1940-6207.CAPR-11-0090

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prediagnostic endogenous sex steroid hormone levels have well established associations with overall risk of breast cancer. While evidence toward the existence of distinct subtypes of breast cancer accumulates, few studies have investigated the associations of sex steroid hormone levels with risk of hormone receptor [estrogen receptor (ER) and/or progesterone receptor (PR)] defined breast cancer. In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. A total of 554 women who developed invasive breast cancer with information on receptor status were matched with 821 control subjects. Conditional logistic regression models estimated breast cancer risk with hormone concentrations according to hormone receptor status of the tumor. Sex steroid hormones were associated with risks of not only ER+PR+ breast cancer [estradiol OR for highest vs. lowest tertile = 2.91 (95% CI: 1.62-5.23), P-trend 0.002; testosterone OR = 2.27 (95% CI: 1.35-3.81), P-trend 0.002] but also of ER-PR- breast cancer [estradiol OR = 2.11 (95% CI: 1.00-4.46), P-trend = 0.05; testosterone OR = 2.06 (95% CI: 0.95-4.46), P-trend = 0.03], with associations appearing somewhat stronger in the receptor-positive disease. Serum androgens and estrogens are associated with risks of both hormone receptor-negative as well as receptor-positive breast tumors. Further research is needed to establish through which molecular pathways, and during which evolutionary stages of development, androgens and estrogens can promote the occurrence of both receptor-positive and -negative clinical breast tumors. Cancer Prev Res; 4(10); 1626-35. (C)2011 AACR.

引用

页码：1626 / 1635

页数：10

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