Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement

被引：20

作者：

Gu, Yufan ^{[1
,2
]}

Hu, Qing ^{[2
]}

Sun, Jian ^{[2
]}

Yu, Hong ^{[2
]}

Pan, Huiqin ^{[2
]}

Zhao, Xiaotong ^{[2
]}

Ji, Shen ^{[1
,2
]}

机构：

[1] China State Inst Pharmaceut Ind, 285 Gebaini Rd, Shanghai 201203, Peoples R China

[2] Shanghai Inst Food & Drug Control, NMPA Key Lab Qual Control Tradit Chinese Med, 1500 Zhangheng Rd, Shanghai 201203, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2020年 / 185卷

关键词：

Hydroxycarbodenafil; Sildenafil analogue; Adulterated health supplement; HR-MS and NMR; STRUCTURE ELUCIDATION; ERECTILE DYSFUNCTION; DIETARY-SUPPLEMENTS; 5; INHIBITORS; UPDATE;

D O I：

10.1016/j.jpba.2020.113222

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

During routine screening of illegal adulterants in health supplements, a novel sildenafil analogue was discovered, and subsequently isolated by recrystallization. Its structure was elucidated by extensive analyses of high resolution mass spectrometry (HR-MS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data. The analogue was finally determined as hydroxycarbodenafil, featuring a hydroxyethyl group instead of an ethyl group on piperazine ring in comparison with carbodenafil. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：6

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