Five Years of siRNA Delivery: Spotlight on Gold Nanoparticles

被引：72

作者：

Lytton-Jean, Abigail K. R. ^{[1
,6
]}

Langer, Robert ^{[1
,2
,3
]}

Anderson, Daniel G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] MIT, H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] MIT, Div Hlth Sci, Cambridge, MA 02139 USA

[5] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[6] MIT, Langer Anderson Labs, Cambridge, MA 02139 USA

来源：

SMALL | 2011年 / 7卷 / 14期

基金：

美国国家卫生研究院;

关键词：

SCAVENGER RECEPTORS; INTERFERING RNA; RECENT PROGRESS; GENE-REGULATION; IN-VIVO; DNA; PERSPECTIVES; MONOLAYERS; INDUCTION; LIVER;

D O I：

10.1002/smll.201100761

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles have become widely used in scientific research due to their unique physical and chemical properties. In the last several years their use as siRNA delivery agents has been investigated. Here, progress made using gold nanoparticles for siRNA delivery is described and the different strategies employed are compared.

引用

页码：1932 / 1937

页数：6

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