Protein Chemical Synthesis by Ligation of Peptide Hydrazides

被引：628
|
作者：
Fang, Ge-Min [1 ]
Li, Yi-Ming [1 ]
Shen, Fei [1 ]
Huang, Yi-Chao [1 ]
Li, Jia-Bin [1 ]
Lin, Yun [1 ]
Cui, Hong-Kui [1 ]
Liu, Lei [1 ]
机构：
[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期
关键词：
native chemical ligation; peptide hydrazides; protein chemical synthesis; protein design; proteins; KINETICALLY CONTROLLED LIGATION; SOLID-PHASE SYNTHESIS; POLYPEPTIDES; FRAGMENTS; MECHANISM; SEGMENTS; SEQUENCE; INSIGHTS; SUPPORT; RESIN;
D O I：
10.1002/anie.201100996
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a "thioester synthon", one that is stable to the conditions of native chemical ligation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7645 / 7649
页数：5
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