Protein Chemical Synthesis by Ligation of Peptide Hydrazides

被引：630

作者：

Fang, Ge-Min ^{[1
]}

Li, Yi-Ming ^{[1
]}

Shen, Fei ^{[1
]}

Huang, Yi-Chao ^{[1
]}

Li, Jia-Bin ^{[1
]}

Lin, Yun ^{[1
]}

Cui, Hong-Kui ^{[1
]}

Liu, Lei ^{[1
]}

机构：

[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期

关键词：

native chemical ligation; peptide hydrazides; protein chemical synthesis; protein design; proteins; KINETICALLY CONTROLLED LIGATION; SOLID-PHASE SYNTHESIS; POLYPEPTIDES; FRAGMENTS; MECHANISM; SEGMENTS; SEQUENCE; INSIGHTS; SUPPORT; RESIN;

D O I：

10.1002/anie.201100996

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a "thioester synthon", one that is stable to the conditions of native chemical ligation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7645 / 7649

页数：5

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