Host Transcription Factors in Hepatitis B Virus RNA Synthesis

被引：65

作者：

Turton, Kristi L. ^{[1
]}

Meier-Stephenson, Vanessa ^{[1
,2
]}

Badmalia, Maulik D. ^{[1
]}

Coffin, Carla S. ^{[2
,3
]}

Patel, Trushar R. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Lethbridge, Dept Chem & Biochem, Alberta RNA Res & Training Inst, 4401 Univ Dr W, Lethbridge, AB T1K 3M4, Canada

[2] Univ Calgary, Dept Microbiol Immunol & Infect Dis, Sch Med, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada

[3] Univ Calgary, Div Gastroenterol & Hepatol, Dept Med, 1403 29 St NW, Calgary, AB T2N 2T9, Canada

[4] Univ Alberta, Discovery Lab, Fac Med & Dent, Katz Ctr Hlth Res 6 010, Edmonton, AB T6G 2E1, Canada

[5] Univ Alberta, Li Ka Shing Inst Virol, Katz Ctr Hlth Res 6 010, Edmonton, AB T6G 2E1, Canada

来源：

VIRUSES-BASEL | 2020年 / 12卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

hepatitis B virus (HBV); viral replication; transcription factors; covalently closed circular DNA (cccDNA); host-viral interactions; NF-KAPPA-B; FARNESOID-X-RECEPTOR; SMALL HETERODIMER PARTNER; DNA-BINDING DOMAIN; NUCLEAR FACTOR 6; NUCLEOCAPSID PROMOTER VARIANT; INHIBITS HBV TRANSCRIPTION; SMAD-INTERACTING PROTEIN-1; SURFACE-ANTIGEN PROMOTER; GENE-EXPRESSION;

D O I：

10.3390/v12020160

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein-HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors' interactions with HBV cccDNA is discussed.

引用

页数：29

共 297 条

[1] EXPANSION OF CREBS DNA RECOGNITION SPECIFICITY BY TAX RESULTS FROM INTERACTION WITH ALA-ALA-ARG AT POSITIONS-282-284 NEAR THE CONSERVED DNA-BINDING DOMAIN OF CREB [J].