New plastoquinones isolated from the brown alga, Sargassum micracanthum

被引：42

作者：

Mori, J

Iwashima, M

Wakasugi, H

Saito, H

Matsunaga, T

Ogasawara, M

Takahashi, S

Suzuki, H

Hayashi, T

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[2] Lead Chem Co Ltd, Dept Pharmaceut Res, Toyama 9300912, Japan

[3] Toyama Prefectural Inst Pharmaceut Res, Toyama 9390363, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 09期

关键词：

plastoquinone; antioxidative activity; lipid peroxidation; radical scavenger; cytotoxic activity; Sargassum micracanthum;

D O I：

10.1248/cpb.53.1159

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.

引用

页码：1159 / 1163

页数：5

共 5 条

[1] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].