Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study

被引：16

作者：

Kim, Ye An ^{[1
]}

Yoon, Ji Won ^{[2
]}

Lee, Young ^{[3
]}

Choi, Hyuk Jin ^{[2
]}

Yun, Jae Won ^{[3
]}

Bae, Eunsin ^{[3
]}

Kwon, Seung-Hyun ^{[3
]}

Ahn, So Eun ^{[4
]}

Do, Ah-Ra ^{[4
]}

Jin, Heejin ^{[5
]}

Won, Sungho ^{[4
,5
,6
]}

Park, Do Joon ^{[7
]}

Shin, Chan Soo ^{[7
]}

Seo, Je Hyun ^{[3
]}

机构：

[1] Vet Hlth Serv Med Ctr, Dept Internal Med, Div Endocrinol, Seoul, South Korea

[2] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Seoul, South Korea

[3] Vet Hlth Serv Med Ctr, Vet Med Res Inst, 53 Jinhwangdo Ro 61 Gil, Seoul 05368, South Korea

[4] Seoul Natl Univ, Dept Publ Hlth Sci, Seoul, South Korea

[5] Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea

[6] RexSoft Inc, Seoul, South Korea

[7] Seoul Natl Univ, Dept Internal Med, Seoul, South Korea

来源：

ENDOCRINOLOGY AND METABOLISM | 2021年 / 36卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Vitamin D deficiency; Genome-wide association study; Asians; Genetic predisposition to disease; Polymorphism; single nucleotide; D-BINDING; PROTEIN; METAANALYSIS; METABOLISM;

D O I：

10.3803/EnM.2021.1241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

research. The Institutional Review Board of Seoul National University Hospital approved the storage of blood samples for genetic analysis with informed consent (IRB No. H-1103-127-357). KARE cohort (KARE, Korean Association Resource; Ansan/ Ansung study): This study was conducted with bioresources from National Biobank of Korea, the Korea Disease Control and Prevention Agency, Republic of Korea (KBN-2019-054). VHSMC cohort (Veterans Health Service Medical Center): This study was conducted thanks to bioresources from the Veterans Medical Research Institute Biobank, Republic of Korea (VBP-2020-02). We would like to thank RexSoft for providing technical support for the Korean-Chip data quality control and supporting imputation analysis. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health and by the NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS.

引用

页码：1189 / 1200

页数：12

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