One-Pot Synthesis of Novel Antiproliferative 9-Aminoacridines

被引：13
作者：
Gellerman, Gary [1 ]
Waintraub, Sagiv [1 ,2 ]
Albeck, Amnon [2 ]
Gaisin, Vladimir [1 ]
机构：
[1] Ariel Univ, Dept Biol Chem, Ctr Samaria, IL-40700 Ariel, Israel
[2] Bar Ilan Univ, Dept Chem, Julius Spokojny Bioorgan Chem Lab, IL-52900 Ramat Gan, Israel
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 22期
关键词：
9-Aminoacridine; addition-elimination; Nucleophilic substitution; one-pot synthesis; anticancer; Quinones; ACRIDINE-DERIVATIVES; ANTITUMOR-ACTIVITY; AGENTS; INHIBITORS; REDUCTASE;
D O I：
10.1002/ejoc.201100133
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Highly efficient one-pot syntheses of antiproliferative 9-aminoacridine (9-AA) derivatives are described. Simple SNAr and addition/elimination reactions, using readily accessible starting materials, give a fast entry to novel 9-(pyridylamino)acridines, 9-(pyrimidinylamino)acridines and potential "dual-function" bioreductive 9-(acridinylamino)quinone intercalators. The synthetic routes reported in this work are general and readily applicable, significantly expanding the range and scope of potential 9-AA anticancer candidates.
引用
收藏
页码：4176 / 4182
页数：7
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