Synthesis of water dispersible and biocompatible nanodiamond composite via photocatalytic surface grafting of zwitterionic polymers for intracellular delivery of DOX

被引：9

作者：

Dai, Lijing ^{[1
]}

Liu, Meiying ^{[1
,2
]}

Long, Wei ^{[1
,2
]}

Hu, Xin ^{[1
]}

Ouyang, Hui ^{[2
]}

Feng, Yulin ^{[2
]}

Deng, Fengjie ^{[1
]}

Wen, Yuanqing ^{[1
]}

Zhang, Xiaoyong ^{[1
]}

Wei, Yen ^{[3
,4
,5
,6
,7
]}

机构：

[1] Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat Tradit Chinese Med, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China

[3] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[4] Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China

[5] Chung Yuan Christian Univ, Dept Chem, Chungli 32023, Taiwan

[6] Chung Yuan Christian Univ, Ctr Nanotechnol, Chungli 32023, Taiwan

[7] Chung Yuan Christian Univ, Inst Biomed Technol, Chungli 32023, Taiwan

来源：

MATERIALS TODAY COMMUNICATIONS | 2022年 / 30卷

基金：

中国国家自然科学基金;

关键词：

ND-based polymeric composites; Photo-induced ATRP; Intracellular drug delivery; FeBr3 as photocatalyst; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS; NANOMATERIALS; CHEMOTHERAPY; ATRP;

D O I：

10.1016/j.mtcomm.2021.103010

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

As a member of nano-carbon compound, nanodiamonds (ND) with diverse structure, small size and relative low toxicity has been extensively explored for different applications especially as delivery vehicles for drugs. However, surface functionalization of ND with polymers is still required to overcome their poor water dispersibility and improve drug delivery performance. In this work, we reported a simple photocatalytic atom transfer radical polymerization (ATRP) method for surface functionalization of ND by using FeBr3 as the photoredox catalyst. Owing to the introduction of water dispersible 2-methacryloyloxyethyl phosphorylcholine (MPC), resultant NDs-MPC displayed improved water dispersibility and low toxicity. The anticancer agent DOX could be loaded on NDs-MPC efficiently and controlled release from ND-P-DOX complexes. The cell viability and cell imaging results demonstrated that DOX can be transported into cells and maintained its corresponding therapeutic effect. More importantly, as compared with traditional ATRP, photocatalytic ATRP could not only operate under rather mild conditions but also could avoid utilization of expensive and toxic agents. Considered the advantages of photocatalytic ATRP and ND, the method developed in this work could be a promising strategy for fabrication of multifunctional ND-based composites for different applications.

引用

页数：9