Thrombocytopenia in patients with myelofibrosis: management options in the era of JAK inhibitor therapy

被引：8

作者：

Benevolo, Giulia ^{[1
]}

Elli, Elena M. ^{[2
]}

Guglielmelli, Paola ^{[3
]}

Ricco, Alessandra ^{[4
]}

Maffioli, Margherita ^{[5
]}

机构：

[1] AOU Citta Salute & Sci, Hematol, Turin, Italy

[2] San Gerardo Hosp, Hematol Div & Bone Marrow Unit, Monza, Italy

[3] Univ Florence, Azienda Osped Univ Careggi, CRIMM Ctr Ric & Innovaz Malattie Mieloproliferat, Dept Expt & Clin Med, Florence, Italy

[4] Univ Bari, Dept Emergency & Organ Transplantat DETO, Hematol Sect, Bari, Italy

[5] Univ Insubria, Dept Med & Surg, Hematol, Varese, Italy

来源：

LEUKEMIA & LYMPHOMA | 2020年 / 61卷 / 07期

关键词：

Myelofibrosis; prognosis; JAK inhibitors; ruxolitinib; thrombocytopenia; PROGNOSTIC SCORING SYSTEM; POST-ESSENTIAL THROMBOCYTHEMIA; INTERNATIONAL WORKING GROUP; LOW-DOSE THALIDOMIDE; MYELOID METAPLASIA; POLYCYTHEMIA-VERA; AVAILABLE THERAPY; OPEN-LABEL; PREDICT SURVIVAL; RUXOLITINIB;

D O I：

10.1080/10428194.2020.1728752

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myelofibrosis (MF), either appearing de novo (primary MF, PMF) or after a previous diagnosis of essential thrombocythemia or of polycythemia vera, is a progressive disease burdened by symptomatic splenomegaly, debilitating systemic symptoms, ineffective hematopoiesis, and overall reduced survival. Patients often present worsening cytopenias, including thrombocytopenia, secondary to progression of the disease as well as to cytoreductive treatment. Patients with MF and thrombocytopenia have few therapeutic options and there is limited information regarding the management of disease in these settings. This article reviews current evidence for the management of patients with MF and thrombocytopenia, in the era of JAK inhibitors.

引用

页码：1535 / 1547

页数：13

共 73 条

[11] Dynamic International Prognostic Scoring System scores, pre-transplant therapy and chronic graft-versus-host disease determine outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis [J].

Ditschkowski, Markus ;

Elmaagacli, Ahmet H. ;

Trenschel, Rudolf ;

Gromke, Tanja ;

Steckel, Nina K. ;

Koldehoff, Michael ;

Beelen, Dietrich W. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (10) :1574-1581

[12] Comprehensive clinical-molecular transplant scoring system for myelofibrosis undergoing stem cell transplantation [J].

Gagelmann, Nico ;

Ditschkowski, Markus ;

Bogdanov, Rashit ;

Bredin, Swann ;

Robin, Marie ;

Cassinat, Bruno ;

Shahswar, Rabia ;

Thol, Felicitas ;

Heuser, Michael ;

Socie, Gerard ;

Beelen, Dietrich ;

Triviai, Ioanna ;

Badbaran, Anita ;

Kroeger, Nicolaus .

BLOOD, 2019, 133 (20) :2233-2242

[13] DIPSS Plus: A Refined Dynamic International Prognostic Scoring System for Primary Myelofibrosis That Incorporates Prognostic Information From Karyotype, Platelet Count, and Transfusion Status [J].

Gangat, Naseema ;

Caramazza, Domenica ;

Vaidya, Rakhee ;

George, Geeta ;

Begna, Kebede ;

Schwager, Susan ;

Van Dyke, Daniel ;

Hanson, Curtis ;

Wu, Wenting ;

Pardanani, Animesh ;

Cervantes, Francisco ;

Passamonti, Francesco ;

Tefferi, Ayalew .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (04) :392-397

[14] Results of PAC203: A Randomized Phase 2 Dose-Finding Study and Determination of the Recommended Dose of Pacritinib [J].

Gerds, Aaron T. ;

Savona, Michael R. ;

Scott, Bart L. ;

Talpaz, Moshe ;

Egyed, Miklos ;

Harrison, Claire N. ;

Yacoub, Abdulraheem ;

Vannucchi, Alessandro M. ;

Mead, Adam J. ;

O'Sullivan, Jennifer ;

Buckley, Sarah A. ;

Mould, Diane R. ;

Tyavanagimatt, Shanthakumar ;

Smith, Jennifer A. ;

Mascarenhas, John .

BLOOD, 2019, 134

[15] A Phase 2 Study of Luspatercept in Patients with Myelofibrosis-Associated Anemia [J].

Gerds, Aaron T. ;

Vannucchi, Alessandro M. ;

Passamonti, Francesco ;

Kremyanskaya, Marina ;

Gotlib, Jason R. ;

Palmer, Jeanne M. ;

McCaul, Kelly ;

Ribrag, Vincent ;

Mead, Adam J. ;

Harrison, Claire N. ;

Mesa, Ruben A. ;

Kiladjian, Jean-Jacques ;

Barosi, Giovanni ;

Gale, Robert Peter ;

Laadem, Abderrahmane ;

Pariseau, Joseph ;

Gerike, Torsten ;

Zhang, Jennie ;

Linde, Peter G. ;

Reynolds, Joseph G. ;

Verstovsek, Srdan .

BLOOD, 2019, 134

[16] Thalidomide in myelofibrosis with myeloid metaplasia: A pooled-analysis of individual patient data from five studies [J].

Giovanni, B ;

Michelle, E ;

Letizia, C ;

Filippo, B ;

Paolo, PP ;

Giuseppe, V ;

Monia, M ;

Gabriele, P ;

Francesca, Z ;

Ayalew, T .

LEUKEMIA & LYMPHOMA, 2002, 43 (12) :2301-2307

[17] Ruxolitinib Enhances Platelet Production in Patients With Thrombocytopenic Myelofibrosis [J].

Grunwald, Michael R. ;

Spivak, Jerry L. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (05) :E38-E40

[18] MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis [J].

Guglielmelli, Paola ;

Lasho, Terra L. ;

Rotunno, Giada ;

Mudireddy, Mythri ;

Mannarelli, Carmela ;

Nicolosi, Maura ;

Pacilli, Annalisa ;

Pardanani, Animesh ;

Rumi, Elisa ;

Rosti, Vittorio ;

Hanson, Curtis A. ;

Mannelli, Francesco ;

Ketterling, Rhett P. ;

Gangat, Naseema ;

Rambaldi, Alessandro ;

Passamonti, Francesco ;

Barosi, Giovanni ;

Barbui, Tiziano ;

Cazzola, Mario ;

Vannucchi, Alessandro M. ;

Tefferi, Ayalew .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04) :310-+

[19] JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis [J].

Harrison, Claire ;

Kiladjian, Jean-Jacques ;

Al-Ali, Haifa Kathrin ;

Gisslinger, Heinz ;

Waltzman, Roger ;

Stalbovskaya, Viktoriya ;

McQuitty, Mari ;

Hunter, Deborah S. ;

Levy, Richard ;

Knoops, Laurent ;

Cervantes, Francisco ;

Vannucchi, Alessandro M. ;

Barbui, Tiziano ;

Barosi, Giovanni .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (09) :787-798

[20] Fedratinib Induces Spleen Responses in Patients with Myeloproliferative Neoplasm-Associated Intermediate- or High-Risk Myelofibrosis (MF) Previously Exposed to Ruxolitinib (RUX), Regardless of Reason for Discontinuing RUX [J].

Harrison, Claire N. ;

Schaap, Nicolaas ;

Vannucchi, Alessandro M. ;

Kiladjian, Jean-Jacques ;

Jourdan, Eric ;

Silver, Richard T. ;

Schouten, Harry C. ;

Passamonti, Francesco ;

Zweegman, Sonja ;

Talpaz, Moshe ;

Verstovsek, Srdan ;

Rose, Shelonitda ;

Shen, Juan ;

Berry, Tymara ;

Brownstein, Carrie ;

Mesa, Ruben A. .

BLOOD, 2019, 134

← 1 2 3 4 5 6 7 8 →