Developments in the production of biological and synthetic binders for immunoassay and sensor-based detection of small molecules

被引：63

作者：

Fodey, Terry ^{[2
]}

Leonard, Paul ^{[3
,4
,5
]}

O'Mahony, John ^{[1
]}

O'Kennedy, Richard ^{[3
,4
,5
]}

Danaher, Martin ^{[1
]}

机构：

[1] TEAGASC, Ashtown Food Res Ctr, Dublin 15, Ireland

[2] Queens Univ Belfast, Sch Biol Sci, Inst Agri Food & Land Use, Belfast, Antrim, North Ireland

[3] Dublin City Univ, Natl Ctr Sensor Res, Dublin 9, Ireland

[4] Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

[5] Dublin City Univ, Biomed Diagnost Inst, Dublin 9, Ireland

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2011年 / 30卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

Antibody; Aptamer; Binding protein; Biorecognition; Immunoassay; Molecular-imprinted polymer; Nanobody; Protein scaffold; Single-chain variable fragment; Synthetic binder; CHEMICAL WARFARE AGENTS; VARIABLE FRAGMENT ANTIBODY; PHAGE DISPLAY TECHNOLOGY; SOLID-PHASE EXTRACTION; SINGLE-CHAIN ANTIBODY; CYANOBACTERIAL HEPATOTOXINS; ELECTROCHEMICAL BIOSENSOR; DEGRADATION-PRODUCTS; IMPRINTED POLYMERS; BINDING-PROTEINS;

D O I：

10.1016/j.trac.2010.10.011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The need for chemical and biological entities of predetermined selectivity and affinity towards target analytes is greater than ever, in applications such as environmental monitoring, bioterrorism detection and analysis of natural toxin contaminants in the food chain. In this review, we focus on advances in the production of specific binders, in terms of both natural entities (e.g., antibodies) and synthetic binders (e.g., molecularly-imprinted polymers). We discuss the potential of emerging technologies for integration into immunoassay and sensing techniques. We place special emphasis on use of these technologies in bioanalytical applications. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：254 / 269

页数：16

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