Multicomponent Syntheses to Alkene- and Alkyne-Functionalized Benzopyrans via Alkynylation and [4+2] Cyclization in One-Pot Process

被引：4

作者：

Shao, Jidong

Li, Liqi

Zhang, Jie

Tian, Tian

Xue, Jijun ^{[1
]}

Zhang, Yuan

Li, Ying

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

SYNLETT | 2015年 / 26卷 / 06期

关键词：

one-pot; multicomponent; alkynylation; 4+2] cyclization; benzopyran; PRIVILEGED STRUCTURES; COMBINATORIAL LIBRARIES; MURRAYA EUCHRESTIFOLIA; CATALYZED CYCLIZATION; QUINONE METHIDES; CHROMANS; CHEMISTRY; CASCADE; SALICYLALDEHYDES; CYCLOADDITION;

D O I：

10.1055/s-0034-1380118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel multicomponent synthesis was found to be an efficient and elegant approach to 2,4-difunctionalized benzopyrans. This sequence includes ZnMe2-promoted alkynylation of salicylaldehyde and ZnCl2-mediated [4+2] cyclization proceeding in sequence of a one-pot process, providing a series of benzopyrans with good diastereoselectivities and moderate yields (dr 20:1 to 4:1). These products are potential precursors and bioactive core skeletons of natural products.

引用

收藏

页码：827 / 833

页数：7

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