The+4259A > C polymorphism of TIM-3 but not-1637C > T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population

被引:6
作者
Pouladian, Masoumeh [1 ]
Ganjalikhani-Hakemi, Mazdak [1 ]
Alsahebfosul, Fereshteh [1 ]
Homayouni, Vida [1 ]
Khosravi, Sharifeh [2 ]
Etemadifar, Masoud [3 ]
Mazrouei, Fariba [1 ]
Salehi, Rasoul [2 ]
机构
[1] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran
[2] Isfahan Univ Med Sci, Sch Med, Dept Cellular & Mol Biol, Esfahan, Iran
[3] Isfahan Univ Med Sci, Al Zahra Hosp, Dept Neurosci, Esfahan, Iran
关键词
TIM-1; TIM-3; Multiple sclerosis; Polymorphism; RHEUMATOID-ARTHRITIS; CELL IMMUNOGLOBULIN; GENE POLYMORPHISMS; PROMOTER; ASTHMA; TH1; AUTOIMMUNE; RECEPTORS; PROTEINS; FAMILY;
D O I
10.1016/j.msard.2017.09.031
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) which initiated and mediated by autoreactive T helper1 cells directed against myelin antigens. One of T cell surface receptors is T cell immunoglobulin and mucin domain (TIM) family which its importance in immunology is recently discovered. These molecules have important immunological function by regulation of T effector cells. Methods: In the present study, we analyzed the frequency of + 4259 A>C polymorphism in TIM-3 and -1637C > T polymorphism in TIM-1 gene in MS patients and healthy controls using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. Results: We found that the polymorphism + 4259 A > C in exon 3 of the TIM-3 gene is associated with susceptibility to the MS (P = 0.029, OR (95% CI) = 1.841) but the other polymorphism, -1637T > C, in the promoter region of TIM-1 is not (p= 0.064). Conclusion: Our findings suggest that + 4259 A > C polymorphism in TIM-3 gene may be one of the important genetic factors associated with the MS susceptibility among Iranian populations.
引用
收藏
页码:152 / 156
页数:5
相关论文
共 32 条
[11]   T Cell Ig and Mucin Domain Proteins and Immunity [J].
Kane, Lawrence P. .
JOURNAL OF IMMUNOLOGY, 2010, 184 (06) :2743-2749
[12]   T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis [J].
Khademi, M ;
Illés, Z ;
Gielen, AW ;
Marta, M ;
Takazawa, N ;
Baecher-Allan, C ;
Brundin, L ;
Hannerz, J ;
Martin, C ;
Harris, RA ;
Hafler, DA ;
Kuchroo, VK ;
Olsson, T ;
Piehl, F ;
Wallström, E .
JOURNAL OF IMMUNOLOGY, 2004, 172 (11) :7169-7176
[13]   Dysregulated T cell expression of TIM3 in multiple sclerosis [J].
Koguchi, Ken ;
Anderson, David E. ;
Yang, Li ;
O'Connor, Kevin C. ;
Kuchroo, Vijay K. ;
Hafler, David A. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1413-1418
[14]   TIM polymorphisms-genetics and function [J].
Lee, J. ;
Phong, B. ;
Egloff, A. M. ;
Kane, L. P. .
GENES AND IMMUNITY, 2011, 12 (08) :595-604
[15]  
McIntire J. J., 2004, SPRINGER SEMINARS IM
[16]  
Mete F, 2014, INT J CLIN EXP MED, V7, P1071
[17]   The TIM gene family regulates autoimmune and allergic diseases [J].
Meyers, JH ;
Sabatos, CA ;
Chakravarti, S ;
Kuchroo, VK .
TRENDS IN MOLECULAR MEDICINE, 2005, 11 (08) :362-369
[18]   Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease [J].
Monney, L ;
Sabatos, CA ;
Gaglia, JL ;
Ryu, A ;
Waldner, H ;
Chernova, T ;
Manning, S ;
Greenfield, EA ;
Coyle, AJ ;
Sobel, RA ;
Freeman, GJ ;
Kuchroo, VK .
NATURE, 2002, 415 (6871) :536-541
[19]  
Mou Z, 2010, J INVEST ALLERG CLIN, V20, P3
[20]   Allergic Asthma: Influence of Genetic and Environmental Factors [J].
Mukherjee, Anil B. ;
Zhang, Zhongjian .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (38) :32883-32889