RETRACTED: Preliminary Study on the Therapeutic Effect of Doxorubicin-Loaded Targeting Nanoparticles on Glioma (Retracted Article)

被引：3

作者：

Lan, Weitu ^{[1
]}

Zhang, Hongguang ^{[2
]}

Yang, Bo ^{[3
]}

机构：

[1] Cangzhou Peoples Hosp, Dept Neurosurg, Cangzhou 061000, Hebei, Peoples R China

[2] Gaotang Peoples Hosp, Dept Neurosurg, Liaocheng 252800, Shandong, Peoples R China

[3] Zibo Cent Hosp, Dept Neurosurg, Zibo 255000, Shandong, Peoples R China

来源：

APPLIED BIONICS AND BIOMECHANICS | 2022年 / 2022卷

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; BLOOD-BRAIN-BARRIER; LIPOSOMES; BIOPSY;

D O I：

10.1155/2022/6405400

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Doxorubicin (DOX) is an anthracycline anticancer drug, which is often associated with drug resistance and cytotoxicity. More unfortunately, the biological barrier in the human environment can weaken the efficacy of DOX, such as the blood-brain barrier (BBB). This work attempts to make efforts to solve this problem. We used polyethylene glycol distearoylphosphatidylethanolamine (PEG-DSPE) as a nanocarrier and DOX as a model drug to construct a composite nanodrug (TF-PEG-DSPE/DOX NPs) by coupling transferrin (TF). The results of glioma experiments show that the nanodrug can effectively penetrate BBB to achieve an antitumor effect.

引用

页数：7

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