External globus pallidus stimulation modulates brain connectivity in Huntington's disease

被引：43

作者：

Ligot, Noemie ^{[1
,2
]}

Krystkowiak, Pierre ^{[3
]}

Simonin, Clemence ^{[4
,5
,6
,7
]}

Goldman, Serge ^{[1
,2
]}

Peigneux, Philippe ^{[8
,9
]}

Van Naemen, John ^{[2
]}

Monclus, Michel ^{[2
]}

Lacroix, Simon Frederic ^{[2
]}

Devos, David ^{[4
,5
,6
,7
]}

Dujardin, Kathy ^{[4
,5
,6
,7
]}

Delmaire, Christine ^{[4
,5
,6
,7
]}

Bardinet, Eric ^{[10
]}

Delval, Arnaud ^{[4
,5
,6
,7
]}

Delliaux, Marie ^{[4
,5
,6
,7
]}

Defebvre, Luc ^{[4
,5
,6
,7
]}

Yelnik, Jerome ^{[10
]}

Blond, Serge ^{[4
,5
,11
,12
]}

Destee, Alain ^{[4
,5
,6
,7
]}

De Tiege, Xavier ^{[1
]}

机构：

[1] Univ Libre Bruxelles, ULB Hop Erasme, Lab Cartog Fonct Cerveau, B-1070 Brussels, Belgium

[2] Univ Libre Bruxelles, ULB Hop Erasme, PET Biomed Cyclotron Unit, B-1070 Brussels, Belgium

[3] Amiens Univ Hosp, CNRS, Dept Neurol, UMR 8160, Amiens, France

[4] Univ Lille Nord France, Lille, France

[5] UDSL, Lille, France

[6] EA 2683 MENRT, Lille, France

[7] Movement Disorder Unit, Lille, France

[8] Univ Libre Bruxelles, Dept Neuropsychol, B-1070 Brussels, Belgium

[9] Univ Libre Bruxelles, Funct Neuroimaging Unit, B-1070 Brussels, Belgium

[10] Grp Hosp La Pitie Salpetriere, INSERM, U679, Paris, France

[11] Dept EA 2683 MENRT, Lille, France

[12] CHU Lille, Dept Neurosurg, F-59037 Lille, France

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2011年 / 31卷 / 01期

关键词：

basal ganglia; deep brain stimulation; default-mode network; Huntington's disease; positron emission tomography; FUNCTIONAL CONNECTIVITY; BASAL GANGLIA; MOTOR;

D O I：

10.1038/jcbfm.2010.186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 41-46; doi:10.1038/jcbfm.2010.186; published online 20 October 2010

引用

页码：41 / 46

页数：6

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