Autopsy and Cardiac Magnetic Resonance Image Case of Bevacizumab-Related Cardiomyopathy

被引：3

作者：

Hashimoto, Naoki ^{[1
]}

Kitano, Daisuke ^{[1
]}

Tamaki, Takehiro ^{[1
]}

Koyama, Yutaka ^{[1
,2
]}

Yamada, Akimasa ^{[1
]}

Hatakeyama, Kinta ^{[3
]}

Hao, Hiroyuki ^{[2
]}

Okumura, Yasuo ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Med, Div Cardiol, Tokyo 1738610, Japan

[2] Nihon Univ, Sch Med, Dept Pathol & Microbiol, Div Human Pathol, Tokyo 1738610, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Osaka 5648565, Japan

来源：

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | 2022年 / 9卷 / 07期

关键词：

bevacizumab; cardiomyopathy; congestive heart failure; cardiac magnetic resonance imaging; autopsy; FAILURE;

D O I：

10.3390/jcdd9070208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report an autopsy case of a 69-year-old female with cervical cancer. She was given bevacizumab-containing chemotherapy for 4 months. After two years of chemotherapy, she developed congestive heart failure (CHF) with left ventricular dysfunction. Cardiac magnetic resonance (CMR) imaging revealed late gadolinium enhancement (LGE) of linear mid-wall delayed enhancement located in the basal to the mid-septal wall, suggesting bevacizumab-related cardiotoxicity. Although she was treated with cardioprotective medications and discharged, she eventually died from worsening CHF a year later, and we conducted an autopsy. Histopathological examination revealed diffuse fibrosis in the myocardium, and the area where LGE was present on CMR showed thinning and wavy changes in cardiomyocytes with diffuse interstitial fibrosis and edema.

引用

页数：4

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