New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

被引：13
作者：
Chausov, Denis N. [1 ]
Burmistrov, Dmitriy E. [1 ]
Kurilov, Alexander D. [1 ]
Bunkin, Nikolai F. [1 ,2 ]
Astashev, Maxim E. [1 ]
Simakin, Alexander V. [1 ]
Vedunova, Maria V. [1 ,3 ]
Gudkov, Sergey V. [1 ,3 ]
机构：
[1] Russian Acad Sci, Prokhorov Gen Phys Inst, Vavilova St 38, Moscow 119991, Russia
[2] Bauman Moscow State Tech Univ, Vtoraya Baumanskaya Ul 5, Moscow 105005, Russia
[3] Univ Nizhni Novgorod, Inst Biol & Biomed, 23 Gagarin Ave, Nizhnii Novgorod 603950, Russia
来源：
MATERIALS | 2021年 / 14卷 / 21期
关键词：
ZnO nanoparticles; borosiloxane; antibacterial agents; composite materials; ZNO NANOPARTICLES; FREE-RADICALS; DNA DELIVERY; POLYMER; SURFACE; NANOCOMPOSITES; ANTIOXIDANTS; 8-OXOGUANINE; GENERATION; TRANSPORT;
D O I：
10.3390/ma14216281
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.
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页数：18
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