Designer drugs from designer bugs

被引:0
作者
Weissman, K [1 ]
机构
[1] Univ Cambridge, Cambridge CB2 1TN, England
关键词
D O I
暂无
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
引用
收藏
页码:519 / 521
页数:3
相关论文
共 6 条
[1]  
BROWN P, 1998, GUARDIAN 0423
[2]   Biosynthesis of 2-nor-6-deoxyerythronolide B by rationally designed domain substitution [J].
Liu, L ;
Thamchaipenet, A ;
Fu, H ;
Betlach, M ;
Ashley, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (43) :10553-10554
[3]   Engineering broader specificity into an antibiotic-producing polyketide synthase [J].
Marsden, AFA ;
Wilkinson, B ;
Cortés, J ;
Dunster, NJ ;
Staunton, J ;
Leadlay, PF .
SCIENCE, 1998, 279 (5348) :199-202
[4]   Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives [J].
Ruan, X ;
Pereda, A ;
Stassi, DL ;
Zeidner, D ;
Summers, RG ;
Jackson, M ;
Shivakumar, A ;
Kakavas, S ;
Staver, MJ ;
Donadio, S ;
Katz, L .
JOURNAL OF BACTERIOLOGY, 1997, 179 (20) :6416-6425
[5]   Biosynthesis of erythromycin and rapamycin [J].
Staunton, J ;
Wilkinson, B .
CHEMICAL REVIEWS, 1997, 97 (07) :2611-2629
[6]   REVIVING THE ANTIBIOTIC MIRACLE [J].
TRAVIS, J .
SCIENCE, 1994, 264 (5157) :360-362