Drug development in IBD: from novel target identification to early clinical trials

被引：41

作者：

Danese, Silvio ^{[1
]}

Fiocchi, Claudio ^{[2
,3
]}

Panes, Julian ^{[4
]}

机构：

[1] Humanitas Univ, Humanitas Res Hosp, Dept Gastroenterol, IBD Ctr, Milan, Italy

[2] Inst Digest Dis, Dept Gastroenterol & Hepatol, Cleveland, OH USA

[3] Cleveland Clin Fdn, Lerner Res Inst, Dept Pathobiol, 9500 Euclid Ave, Cleveland, OH 44195 USA

[4] Hosp Clin Barcelona, Dept Gastroenterol, IDIBAPS, CIBERehd, Barcelona, Spain

来源：

GUT | 2016年 / 65卷 / 08期

关键词：

INFLAMMATORY-BOWEL-DISEASE; RECOMBINANT HUMAN INTERLEUKIN-10; ACTIVE CROHNS-DISEASE; TUMOR-NECROSIS-FACTOR; ANIMAL-MODELS; ULCERATIVE-COLITIS; INTESTINAL INFLAMMATION; MAINTENANCE INFLIXIMAB; CYTOKINE PRODUCTION; RANDOMIZED-TRIAL;

D O I：

10.1136/gutjnl-2016-311717

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

[No abstract available]

引用

页码：1233 / 1239

页数：7

共 63 条

[1] In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease [J].

Atreya, Raja ;

Neumann, Helmut ;

Neufert, Clemens ;

Waldner, Maximilian J. ;

Billmeier, Ulrike ;

Zopf, Yurdaguel ;

Willma, Marcus ;

App, Christine ;

Muenster, Tino ;

Kessler, Hermann ;

Maas, Stefanie ;

Gebhardt, Bernd ;

Heimke-Brinck, Ralph ;

Reuter, Eva ;

Doerje, Frank ;

Rau, Tilman T. ;

Uter, Wolfgang ;

Wang, Thomas D. ;

Kiesslich, Ralf ;

Vieth, Michael ;

Hannappel, Ewald ;

Neurath, Markus F. .

NATURE MEDICINE, 2014, 20 (03) :313-318

[2] Network medicine: a network-based approach to human disease [J].

Barabasi, Albert-Laszlo ;

Gulbahce, Natali ;

Loscalzo, Joseph .

NATURE REVIEWS GENETICS, 2011, 12 (01) :56-68

[3] Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses [J].

Berg, DJ ;

Davidson, N ;

Kuhn, R ;

Muller, W ;

Menon, S ;

Holland, G ;

ThompsonSnipes, L ;

Leach, MW ;

Rennick, D .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (04) :1010-1020

[4] ALPHA-4-BETA-7-INTEGRIN MEDIATES LYMPHOCYTE BINDING TO THE MUCOSAL VASCULAR ADDRESSIN MADCAM-1 [J].

BERLIN, C ;

BERG, EL ;

BRISKIN, MJ ;

ANDREW, DP ;

KILSHAW, PJ ;

HOLZMANN, B ;

WEISSMAN, IL ;

HAMANN, A ;

BUTCHER, EC .

CELL, 1993, 74 (01) :185-195

[5]

BEST WR, 1976, GASTROENTEROLOGY, V70, P439

[6] Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease [J].

Biancheri, Paolo ;

Brezski, Randall J. ;

Di Sabatino, Antonio ;

Greenplate, Allison R. ;

Soring, Keri L. ;

Corazza, Gino R. ;

Kok, Klaartje B. ;

Rovedatti, Laura ;

Vossenkaemper, Anna ;

Ahmad, Nadja ;

Snoek, Susanne A. ;

Vermeire, Severine ;

Rutgeerts, Paul ;

Jordan, Robert E. ;

MacDonald, Thomas T. .

GASTROENTEROLOGY, 2015, 149 (06) :1564-+

[7] Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis [J].

Brandse, Johannan F. ;

van den Brink, Gijs R. ;

Wildenberg, Manon E. ;

van der Kleij, Desiree ;

Rispens, Theo ;

Jansen, Jeroen M. ;

Mathot, Ron A. ;

Ponsioen, Cyriel Y. ;

Lowenberg, Mark ;

D'Haens, Geert R. A. M. .

GASTROENTEROLOGY, 2015, 149 (02) :350-+

[8] Personalizing medicine for autoimmune and inflammatory diseases [J].

Chan, Andrew C. ;

Behrens, Timothy W. .

NATURE IMMUNOLOGY, 2013, 14 (02) :106-109

[9] Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease. [J].

Colombel, Jean Frederic ;

Sandborn, William J. ;

Reinisch, Walter ;

Mantzaris, Gerassimos J. ;

Kornbluth, Asher ;

Rachmilewitz, Daniel ;

Lichtiger, Simon ;

D'Haens, Geert ;

Diamond, Robert H. ;

Broussard, Delma L. ;

Tang, Kezhen L. ;

van der Woude, C. Janneke ;

Rutgeerts, Paul .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (15) :1383-1395

[10] Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial [J].

Colombel, Jean-Frederic ;

Sandborn, William J. ;

Rutgeerts, Paul ;

Enns, Robert ;

Hanauer, Stephen B. ;

Panaccione, Remo ;

Schreiber, Stefan ;

Byczkowski, Dan ;

Li, Ju ;

Kent, Jeffrey D. ;

Pollack, Paul F. .

GASTROENTEROLOGY, 2007, 132 (01) :52-65

← 1 2 3 4 5 6 7 →