Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity

被引：11

作者：

Akiba, Megumi ^{[1
]}

Kinoshita, Kaoru ^{[1
]}

Kino, Yoshihiro ^{[2
]}

Sato, Jun-ichi ^{[2
]}

Koyama, Kiyotaka ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, 2-552-1 Noshio, Kiyose, Tokyo 2048588, Japan

[2] Meiji Pharmaceut Univ, Dept Bioinformat, 2-552-1 Noshio, Kiyose, Tokyo 2048588, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 02期

关键词：

Alzheimer's disease (AD); Amyloid beta aggregation; Thioflavin T; Mushroom; Albatrellus yasudae; Meroterpenoid; DERIVATIVES;

D O I：

10.1016/j.bmcl.2019.126808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease is a serious neurologic disorder that cannot be cured completely. In this study, we targeted compounds that inhibit amyloid-beta (A beta) aggregation, based on the amyloid cascade hypothesis. Ten compounds (1-10) were isolated from CHCl3 extracts of the mushroom Albatrellus yasudae using A beta-aggregation inhibitory activity-guided separation. The structures of these compounds were elucidated from 1D and 2D NMR and MS spectral data. Compounds 1-3 were novel, whereas 4-10 were identified as the known compounds grifolin, grifolic acid, neogrifolin, confluentin, 2-hydroxyneogrifolin, daurichromenic acid, and a cerebroside derivative. Compounds 1-10 were tested for A beta-aggregation inhibitory activity. Compounds 1, 3, 5, 6, 8, and 9 have potential as A beta-aggregation inhibitory activity.

引用

页数：3

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