Creatinine: From physiology to clinical application

被引：235
作者：
Kashani, Kianoush [1 ,2 ]
Rosner, Mitchell H. [3 ]
Ostermann, Marlies [4 ]
机构：
[1] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA
[2] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA
[3] Univ Virginia Hlth Syst, Div Nephrol, Charlottesville, VA USA
[4] Kings Coll London, Guys & St Thomas Hosp, London, England
来源：
EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2020年 / 72卷
关键词：
Creatinine; Creatine; Cystatin C; GFR; Kidney function; Sarcopenia; Muscle mass; GLOMERULAR-FILTRATION-RATE; ACUTE KIDNEY INJURY; CRITICALLY-ILL PATIENTS; SERUM CYSTATIN-C; COOKED MEAT MEAL; RENAL-FUNCTION; PLASMA CREATININE; TUBULAR SECRETION; INTERNATIONAL SOCIETY; CARE MEASUREMENT;
D O I：
10.1016/j.ejim.2019.10.025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Estimating static kidney function accurately and detecting changes in kidney function in a timely fashion are challenging but critically important tasks. Serum creatinine is the most widely used functional biomarker of the kidney. However, its use is associated with substantial shortcomings. Understanding these shortcomings is critical in allowing accurate interpretation of creatinine values and translating them into changes in kidney function. In this review, the pathways involved in creatinine generation and metabolism as well as the techniques involved in measuring creatinine concentrations are discussed. This allows for the discussion of the value and pitfalls in using creatinine as a marker of kidney function. In addition, information regarding alternative functional biomarkers of the kidney is provided.
引用
收藏
页码：9 / 14
页数：6
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