The Role of Resolvins, Protectins and Marensins in Non-Alcoholic Fatty Liver Disease (NAFLD)

被引：16

作者：

Maciejewska-Markiewicz, Dominika ^{[1
]}

Stachowska, Ewa ^{[1
]}

Hawrylkowicz, Viktoria ^{[1
]}

Stachowska, Laura ^{[1
]}

Prowans, Piotr ^{[2
]}

机构：

[1] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-70204 Szczecin, Poland

[2] Pomeranian Med Univ, Clin Plast Endocrine & Gen Surg, PL-72009 Police, Poland

来源：

BIOMOLECULES | 2021年 / 11卷 / 07期

关键词：

NAFLD; n-3; PUFA; resolvins; protectins; marensins; LEUKOTRIENE A(4) HYDROLASE; ANTIINFLAMMATORY ACTIONS; RESOLUTION; MEDIATORS; ACID; D1; INFLAMMATION; STEATOSIS; OMEGA-3-FATTY-ACIDS; ACCUMULATION;

D O I：

10.3390/biom11070937

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased triacylglycerols' (TAG) synthesis, insulin resistance, and prolonged liver lipid storage might lead to the development of non-alcoholic fatty liver disease (NAFLD). Global prevalence of NAFLD has been estimated to be around 25%, with gradual elevation of this ratio along with the increased content of adipose tissue in a body. The initial stages of NAFLD may be reversible, but the exposition to pathological factors should be limited. As dietary factors greatly influence various disease development, scientists try to find dietary components, helping to alleviate the steatosis. These components include n-3 polyunsaturated (PUFA) fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA). This review focused on the role of resolvins, protectins and merensins in NAFLD.

引用

页数：9

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