Greasing the Wheels of Regeneration

被引：7

作者：

Kohen, Rafi ^{[1
]}

Giger, Roman J. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Med, Grad Program Neurosci, 2045 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Cell & Dev Biol, 2045 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Neurol, 2045 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

来源：

NEURON | 2020年 / 105卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2019.11.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron, Yang et al. (2020) identify glycerolipid metabolism as a neuron-intrinsic mechanism that regulates axonal growth and regeneration. Shifting glycerolipid metabolism toward increased triglyceride synthesis blocks PNS neuron regeneration, whereas shifting it toward membrane phospholipid synthesis overcomes regeneration failure in CNS neurons.

引用

页码：207 / 209

页数：3

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