Psiguadials A and B, Two Novel Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava']java

被引：92
|
作者：
Shao, Meng [1 ,2 ]
Wang, Ying [1 ]
Liu, Zhong [3 ]
Zhang, Dong-Mei [1 ,3 ]
Cao, Hui-Hui [1 ,3 ]
Jiang, Ren-Wang [1 ,3 ]
Fan, Chun-Lin [1 ,3 ]
Zhang, Xiao-Qi [1 ,3 ]
Chen, He-Ru [1 ,3 ]
Yao, Xin-Sheng [1 ,3 ]
Ye, Wen-Cai [1 ,2 ,3 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China
[3] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 21期
关键词：
GUAVA; LEAF; L; TRITERPENOIDS; EXTRACTS;
D O I：
10.1021/ol102179u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.
引用
收藏
页码：5040 / 5043
页数：4
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