Psiguadials A and B, Two Novel Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava']java

被引：92

作者：

Shao, Meng ^{[1
,2
]}

Wang, Ying ^{[1
]}

Liu, Zhong ^{[3
]}

Zhang, Dong-Mei ^{[1
,3
]}

Cao, Hui-Hui ^{[1
,3
]}

Jiang, Ren-Wang ^{[1
,3
]}

Fan, Chun-Lin ^{[1
,3
]}

Zhang, Xiao-Qi ^{[1
,3
]}

Chen, He-Ru ^{[1
,3
]}

Yao, Xin-Sheng ^{[1
,3
]}

Ye, Wen-Cai ^{[1
,2
,3
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

[3] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 21期

关键词：

GUAVA; LEAF; L; TRITERPENOIDS; EXTRACTS;

D O I：

10.1021/ol102179u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.

引用

页码：5040 / 5043

页数：4

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