Fractionated stereotactic radiotherapy of glomus Jugulare tumors - Local control, toxicity, symptomatology, and quality of life

被引:37
作者
Henzel, Martin
Hamm, Klaus
Gross, Markus W.
Surber, Gunnar
Kleinert, Gabriele
Failing, Thomas
Sitter, Helmut
Strassmann, Gerd
Engenhart-Cabillic, Rita
机构
[1] Univ Marburg, Dept Radiat Oncol, D-35033 Marburg, Germany
[2] HELIOS Klin, Dept Stereotact Neurosurg & Radiosurg, Erfurt, Germany
[3] Univ Marburg, Dept Theoret Surg, Marburg, Germany
关键词
stereotactic radiotherapy; glomus jugulare tumor; GAMMA-KNIFE RADIOSURGERY; CONFORMAL RADIOTHERAPY; MANAGEMENT; HEAD; MENINGIOMAS; REPRODUCIBILITY; CHEMODECTOMAS; ACCURACY; SURGERY;
D O I
10.1007/s00066-007-1701-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and Purpose: For glomus jugulare tumors, the goal of treatment is microsurgical excision. To minimize postoperative neurologic deficits, stereotactic radiosurgery (SRS) was performed as an alternative treatment option. Stereotactic fractionated radiotherapy (SRT) could be a further alternative. This study aims at the assessment of local control, side effects, and quality of life (QoL). Patients and Methods: Between 1999-2005, 17 patients were treated with SRT. 11/17 underwent previous operations. 6/17 received primary SRT. Treatment was delivered by a linear accelerator with 6-MV photons. Median cumulative dose was 57.0 Gy. Local control, radiologic regression, toxicity, and symptomatology were evaluated half-yearly by clinical examination and MRI scans. QoL was assessed by Short Form-36 (SF-36). Results: Median follow-up was 40 months. Freedom from progression and overall survival for 5 years were 100% and 93.8%. Radiologic regression was seen in 5/16 cases, 11/16 patients were stable. Median tumor shrinkage was 17.9% (p = 0.14). Severe acute toxicity (grade 3-4) or any late toxicity was never seen. Main symptoms improved in 9/16 patients, 7/16 were stable. QoL was not affected in patients receiving primary SRT. Conclusion: SRT offers an additional treatment option of high efficacy with less side effects, especially in cases of large tumors, morbidity, or recurrences after incomplete resections.
引用
收藏
页码:557 / 562
页数:6
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