Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

被引：0

作者：

Renzetti, Andrea ^{[1
]}

Rutherford, Ryan N. ^{[2
]}

Fukumoto, Kozo ^{[3
]}

Kunciw, Dominique ^{[1
]}

Sore, Hannah F. ^{[1
]}

Spring, David R. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

[2] Sci Educ Acad Ryukyus, 1 Senbaru, Nishihara, Okinawa 9030213, Japan

[3] Univ Ryukyus, Fac Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan

来源：

SYNLETT | 2019年 / 30卷 / 19期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 日本科学技术振兴机构; 英国惠康基金;

关键词：

peptides; stapling; linkers; amines; alkynes; click chemistry; ANTIMICROBIAL PEPTIDES; DRUG DESIGN; HELIX;

D O I：

10.1055/s-0039-1690217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Substituted dipropargylamines that are suitable as functionalized linkers for peptide stapling can be synthesized in one step under mild conditions from commercially available starting materials (41% to quantitative yield).

引用

页码：2153 / 2156

页数：4

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