A combined finite-discrete element method for simulating pharmaceutical powder tableting

被引：56
作者：
Lewis, RW
Gethin, DT
Yang, XSS
Rowe, RC
机构：
[1] Univ Coll Swansea, Sch Engn, Civil & Computat Engn Ctr, Swansea SA2 8PP, W Glam, Wales
[2] AstraZeneca Pharmaceut, Macclesfield, Cheshire, England
来源：
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING | 2005年 / 62卷 / 07期
关键词：
discrete element method; elasticity; viscoelasticity; finite element analysis; pharmaceutical powder; tableting;
D O I：
10.1002/nme.1287
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The pharmaceutical powder and tableting process is simulated using a combined finite-discrete element method and contact dynamics for irregular-shaped particles. The particle-scale formulation and two-stage contact detection algorithm which has been developed for the proposed method enhances the overall calculation efficiency for particle interaction characteristics. The irregular particle shapes and random sizes are represented as a pseudo-particle assembly having a scaled up geometry but based on the variations of real powder particles. Our simulations show that particle size, shapes and material properties have a significant influence on the behaviour of compaction and deformation. Copyright (C) 2005 John Wiley Sons, Ltd.
引用
收藏
页码：853 / 869
页数：17
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