The phage-related chromosomal islands of Gram-positive bacteria

被引：282
作者：
Novick, Richard P. [1 ]
Christie, Gail E. [2 ]
Penades, Jose R. [3 ]
机构：
[1] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst Biomol Med,Mol Pathogenesis Program, New York, NY 10016 USA
[2] Virginia Commonwealth Univ, Sch Med Microbiol & Immunol, Richmond, VA 23298 USA
[3] Univ Cardenal Herrera CEU, Dept Quim Bioquim & Biol Mol, Valencia 46113, Spain
来源：
NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 08期
关键词：
TOXIC-SHOCK SYNDROME; RESISTANT STAPHYLOCOCCUS-AUREUS; PATHOGENICITY ISLAND; GENETIC ELEMENT; COMPLETE GENOMES; HELPER PHAGE; PROTEINS; INTEGRASE; EVOLUTION; SEQUENCE;
D O I：
10.1038/nrmicro2393
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.
引用
收藏
页码：541 / 551
页数：11
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