Palladium-Catalyzed C-C Bonds Formation Reactions via Selective C-H Bonds Functionalization

In past decades, palladium-catalyzed direct selective C-H bonds functionalization has become a highly attractive strategy in organic synthesis and represents a highly desirable goal. This review introduces three extensively investigated modes for forming C-C bonds from C-H bonds via palladium catalysis; cross-coupling reactions of C-H bonds with aryl or alkyl halides/pseudohalides, cross-dehydrogenative couplings of two C-H bonds, and cross-coupling reactions of C-H bonds with organometallic reagents. A comprehensive summary of recent advances and detailed analysis on the versatility and practicality of these transformations are presented. The research trend for this strategy is also prospected.