A new strategy for ionization enhancement by derivatization for mass spectrometry

被引：99

作者：

Iwasaki, Yusuke ^{[1
]}

Nakano, Yuki ^{[1
]}

Mochizuki, Keisuke ^{[1
]}

Nomoto, Maki ^{[1
]}

Takahashi, Yuki ^{[1
]}

Ito, Rie ^{[1
]}

Saito, Koichi ^{[1
]}

Nakazawa, Hiroyuki ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2011年 / 879卷 / 17-18期

关键词：

Mass spectrometry; Ionization enhancement; Derivatization; Electrospray ionization; Atmospheric pressure chemical ionization; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; VITAMIN-D METABOLITES; ELECTROSPRAY-IONIZATION; PRECOLUMN DERIVATIZATION; GAS-CHROMATOGRAPHY; CHEMICAL-IONIZATION; QUANTITATIVE-ANALYSIS; HUMAN PLASMA; AMINO-ACIDS;

D O I：

10.1016/j.jchromb.2011.02.008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Liquid chromatography-mass spectrometry (LC-MS) using atmospheric pressure ionization is drastically different from hitherto available analytical methods used to detect polar analytes. The electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources of MS have contributed to the advancement of LC-MS and LC-MS/MS techniques for the analysis of biological samples. However, one major obstacle is the weak ionization of some analytes in the ESI and APCI techniques. In this review, we introduce high-sensitivity methods using several derivatization reagents for ionization enhancement. We also present an overview of chemical derivatization methods that have been applied to small molecules, such as amino acids and steroids, in biological samples. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1159 / 1165

页数：7

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