A new strategy for ionization enhancement by derivatization for mass spectrometry

被引：99

作者：

Iwasaki, Yusuke ^{[1
]}

Nakano, Yuki ^{[1
]}

Mochizuki, Keisuke ^{[1
]}

Nomoto, Maki ^{[1
]}

Takahashi, Yuki ^{[1
]}

Ito, Rie ^{[1
]}

Saito, Koichi ^{[1
]}

Nakazawa, Hiroyuki ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2011年 / 879卷 / 17-18期

关键词：

Mass spectrometry; Ionization enhancement; Derivatization; Electrospray ionization; Atmospheric pressure chemical ionization; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; VITAMIN-D METABOLITES; ELECTROSPRAY-IONIZATION; PRECOLUMN DERIVATIZATION; GAS-CHROMATOGRAPHY; CHEMICAL-IONIZATION; QUANTITATIVE-ANALYSIS; HUMAN PLASMA; AMINO-ACIDS;

D O I：

10.1016/j.jchromb.2011.02.008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Liquid chromatography-mass spectrometry (LC-MS) using atmospheric pressure ionization is drastically different from hitherto available analytical methods used to detect polar analytes. The electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources of MS have contributed to the advancement of LC-MS and LC-MS/MS techniques for the analysis of biological samples. However, one major obstacle is the weak ionization of some analytes in the ESI and APCI techniques. In this review, we introduce high-sensitivity methods using several derivatization reagents for ionization enhancement. We also present an overview of chemical derivatization methods that have been applied to small molecules, such as amino acids and steroids, in biological samples. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1159 / 1165

页数：7

共 88 条

[1] Derivatization of ethinylestradiol with dansyl chloride to enhance electrospray ionization: Application in trace analysis of ethinylestradiol in rhesus monkey plasma [J].

Anari, MR ;

Bakhtiar, R ;

Zhu, B ;

Huskey, S ;

Franklin, RB ;

Evans, DC .

ANALYTICAL CHEMISTRY, 2002, 74 (16) :4136-4144

[2] Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry [J].

Andreoli, R ;

Manini, P ;

Corradi, M ;

Mutti, A ;

Niessen, WMA .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (07) :637-645

[3] Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry [J].

Aronov, Pavel A. ;

Hall, Laura M. ;

Dettmer, Katja ;

Stephensen, Charles B. ;

Hammock, Bruce D. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (05) :1917-1930

[4] Use of S-pentafluorophenyl tris(2,4,6-trimethoxyphenyl) phosphonium acetate bromide and (4-hydrazino-4-oxobutyl) [tris(2,4,6-trimethoxyphenyl)]phosphonium bromide for the derivatization of alcohols, aldehydes and ketones for detection by liquid chromatography/electrospray mass spectrometry [J].

Barry, SJ ;

Carr, RM ;

Lane, SJ ;

Leavens, WJ ;

Manning, CO ;

Monté, S ;

Waterhouse, I .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (05) :484-497

[5] Derivatisation for liquid chromatography/electrospray mass spectrometry:: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives [J].

Barry, SJ ;

Carr, RM ;

Lane, SJ ;

Leavens, WJ ;

Monté, S ;

Waterhouse, I .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (06) :603-620

[6] Improved Sensitivity Mass Spectrometric Detection of Eicosanoids by Charge Reversal Derivatization [J].

Bollinger, James G. ;

Thompson, Wallace ;

Lai, Ying ;

Oslund, Rob C. ;

Hallstrand, Teal S. ;

Sadilek, Martin ;

Turecek, Frantisek ;

Gelb, Michael H. .

ANALYTICAL CHEMISTRY, 2010, 82 (16) :6790-6796

[7] Liquid chromatography-tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver [J].

Bouligand, J ;

Deroussent, A ;

Paci, A ;

Morizet, J ;

Vassal, G .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2006, 832 (01) :67-74

[8] The lipophilicity indices of flavonoids estimated by reversed-phase liquid chromatography using different computation methods [J].

Briciu, Rodica Domnica ;

Kot-Wasik, Agata ;

Namiesnik, Jacek ;

Sarbu, Costel .

JOURNAL OF SEPARATION SCIENCE, 2009, 32 (12) :2066-2074

[9] ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY - CORONA DISCHARGE ION-SOURCE FOR USE IN LIQUID CHROMATOGRAPH MASS SPECTROMETER-COMPUTER ANALYTICAL SYSTEM [J].

CARROLL, DI ;

DZIDIC, I ;

STILLWELL, RN ;

HAEGELE, KD ;

HORNING, EC .

ANALYTICAL CHEMISTRY, 1975, 47 (14) :2369-2373

[10] Derivatisation of carboxylic acid groups in pharmaceuticals for enhanced detection using liquid chromatography with electrospray ionisation tandem mass spectrometry [J].

Cartwright, AJ ;

Jones, P ;

Wolff, JC ;

Evans, EH .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2005, 19 (08) :1058-1062

← 1 2 3 4 5 6 7 8 9 →