Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women

被引：20
作者：
Nagai, Kumiko [1 ]
Kozaki, Koichi [1 ]
Sonohara, Kazuki [1 ]
Akishita, Masahiro [2 ]
Toba, Kenji [1 ]
机构：
[1] Kyorin Univ, Sch Med, Dept Geriatr Med, Tokyo 1818611, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Tokyo, Japan
来源：
GERIATRICS & GERONTOLOGY INTERNATIONAL | 2011年 / 11卷 / 03期
关键词：
interleukin-6; leukoaraiosis; white matter hyperintensity; SMALL-VESSEL DISEASE; C-REACTIVE PROTEIN; ROTTERDAM SCAN; GERIATRIC SYNDROME; LEUKOARAIOSIS; LESIONS; BRAIN; PROGRESSION; BIOMARKERS; DISABILITY;
D O I：
10.1111/j.1447-0594.2010.00686.x
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aim: We evaluated the relationships between serum levels of high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6 with the severity of leukoaraiosis. Methods: One hundred and thirty-seven elderly women who attended the Center for Comprehensive Care on Memory Disorders at Kyorin University Hospital were enrolled in this study. Leukoaraiosis was assessed by periventricular hyperintensity (PVH) score and deep white matter hyperintensity (DWMH) score. Results: Serum log IL-6 level correlated with PVH and DWMH scores, but hsCRP did not. By multinomial logistic analysis, IL-6 was significantly related to DWMH score, independent of age and systolic blood pressure. Conclusion: IL-6 is presumably an important marker of leukoaraiosis, as is the case with silent cerebral infarction. Geriatr Gerontol Int 2011; 11: 328-332.
引用
收藏
页码：328 / 332
页数：5
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