An Intelligent Nanoscale Insulin Delivery System

被引：4

作者：

Wang, Wei ^{[1
,2
]}

Liao, Ling ^{[2
]}

Zhang, Xiaobing ^{[1
,3
]}

Lei, Fan ^{[4
]}

Zhang, Yaou ^{[1
,2
,3
]}

Liu, Gan ^{[5
]}

Xie, Weidong ^{[1
,2
,3
]}

机构：

[1] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Hlth Sci & Technol, Div Life Sci & Hlth, Shenzhen 518055, Peoples R China

[2] Tsinghua Univ, Open FIESTA Ctr, Shenzhen 518055, Peoples R China

[3] Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

[4] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China

[5] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 11期

基金：

中国国家自然科学基金;

关键词：

insulin; diabetes; drug delivery; PAM-PAspPBA-b-PEG; GLUCOSE FLUCTUATION;

D O I：

10.3390/molecules23112945

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin injection relies on strict blood glucose monitoring. However, existing techniques and algorithms for blood glucose monitoring cannot be completed in a timely way. In this study, we have developed a new intelligent glucose-sensitive insulin delivery system to stabilize blood glucose levels in the body. This system does not require real-time detection of blood glucose. First, we successfully synthesized a nanoscale material called PAM-PAspPBA-b-PEG by using chemical methods. We then conducted TEM, DLS, and H-1-NMR analyses to characterize the physicochemical properties, such as size, molecular composition, and configuration of the nanomaterial. We verified the glucose responsibility of the insulin loading nanoscale material in vitro and evaluated its safety and effect on mice in vivo. Results showed that insulin-loaded PAM-PAspPBA-b-PEG is glucose-sensitive, safer and more effective than regular insulin injection. This study provides a basis for future development of smart insulin delivery systems.

引用

页数：12

共 16 条

[1]

Boyle Mary E, 2008, Medsurg Nurs, V17, P383

[2] Novel synergic antidiabetic effects of Astragalus polysaccharides combined with Crataegus flavonoids via improvement of islet function and liver metabolism [J].