Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells

被引：9

作者：

Liu, Xiaoyang ^{[1
,2
]}

Abe-Kanoh, Naomi ^{[1
,3
]}

Liu, Yujia ^{[1
,2
]}

Zhu, Beiwei ^{[2
]}

Munemasa, Shintaro ^{[1
]}

Nakamura, Toshiyuki ^{[1
]}

Murata, Yoshiyuki ^{[1
]}

Nakamura, Yoshimasa ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Environm & Life Sci, Okayama, Japan

[2] Dalian Polytech Univ, Sch Food Sci & Technol, Dalian, Peoples R China

[3] Tokushima Univ, Inst Biomed Sci, Dept Food Sci, Grad Sch, Tokushima, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 11期

关键词：

autophagy; phosphatidylinositide; 3-kinase; Nrf2; Keap1; benzyl isothiocyanate; PATHWAY; RESISTANCE;

D O I：

10.1080/09168451.2017.1374830

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.

引用

页码：2212 / 2215

页数：4

共 17 条

[1] Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells
Abe, N.
Hou, D-X
Munemasa, S.
Murata, Y.
Nakamura, Y.
[J]. CELL DEATH & DISEASE, 2014, 5 : e1534 - e1534
[2] Portrait of the PI3K/AKT pathway in colorectal cancer
Danielsen, Stine Aske
Eide, Peter Wold
Nesbakken, Arild
Guren, Tormod
Leithe, Edward
Lothe, Ragnhild A.
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2015, 1855 (01): : 104 - 121
[3] Multidrug resistance in cancer: Role of ATP-dependent transporters
Gottesman, MM
Fojo, T
Bates, SE
[J]. NATURE REVIEWS CANCER, 2002, 2 (01) : 48 - 58
[4] The complexity of the Nrf2 pathway: beyond the antioxidant response
Huang, Ying
Li, Wenji
Su, Zheng-yuan
Kong, Ah-Ng Tony
[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2015, 26 (12) : 1401 - 1413
[5] Selective turnover of p62/A170/SQSTM1 by autophagy
Ichimura, Yoshinobu
Kominami, Eiki
Tanaka, Keiji
Komatsu, Masaaki
[J]. AUTOPHAGY, 2008, 4 (08) : 1063 - 1066
[6] Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Itakura, Eisuke
Kishi, Chieko
Inoue, Kinji
Mizushima, Noboru
[J]. MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (12) : 5360 - 5372
[7] p62 links autophagy and Nrf2 signaling
Jiang, Tao
Harder, Bryan
de la Vega, Montserrat Rojo
Wong, Pak K.
Chapman, Eli
Zhang, Donna D.
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2015, 88 : 199 - 204
[8] Pathological roles of MAPK signaling pathways in human diseases
Kim, Eun Kyung
Choi, Eui-Ju
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (04): : 396 - 405
[9] Role of Nrf2 in Oxidative Stress and Toxicity
Ma, Qiang
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013, 2013, 53 : 401 - +
[10] Nakamura Y, 2000, CANCER RES, V60, P219

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