Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome

被引：163

作者：

Komaroff, Anthony L. ^{[1
,2
]}

Lipkin, W. Ian ^{[3
]}

机构：

[1] Brigham & Womens Hosp, Div Gen Med, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[3] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY 10027 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 09期

关键词：

EPSTEIN-BARR-VIRUS; OXIDATIVE STRESS; FUNCTIONAL CONNECTIVITY; EXERCISE; DISEASE; BRAIN; INFECTION; ABNORMALITIES; RECEPTORS; SYMPTOMS;

D O I：

10.1016/j.molmed.2021.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also includes a post-coronavirus disease 2019 (COVID-19) syndrome ('long COVID') with features that can follow other acute infectious diseases and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here we summarize what is known about the pathogenesis of ME/CFS and of 'acute' COVID-19, and we speculate that the pathogenesis of post-COVID19 syndrome in some people may be similar to that of ME/CFS. We propose molecular mechanisms that might explain the fatigue and related symptoms in both illnesses, and we suggest a research agenda for both ME/CFS and post- COVID-19 syndrome.

引用

页码：895 / 906

页数：12

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