Delayed ghrelin suppression following oral glucose tolerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls

被引：12

作者：

O'Gorman, Clodagh S. ^{[1
,4
,5
,6
]}

Simoneau-Roy, Judith ^{[1
,4
,5
,6
]}

Pencharz, Paul M. B. ^{[2
,4
,7
]}

Adeli, Khosrow ^{[3
,4
]}

Hamilton, Jill ^{[1
,4
,5
,6
]}

机构：

[1] Univ Toronto, Div Endocrinol, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Div Gastroenterol Hepatol & Nutr, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Div Pediat Lab Med, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Dept Paediat, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Hosp Sick Children, Res Inst, Toronto, ON M5S 1A1, Canada

[6] Univ Toronto, Physiol & Expt Med Program, Toronto, ON M5S 1A1, Canada

[7] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 1A1, Canada

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY | 2011年 / 6卷 / 3-4期

关键词：

Hypothalamic obesity; craniopharyngioma; ghrelin; satiety hormones; PUBERTAL CHANGES; FOOD-INTAKE; OVERWEIGHT; SECRETION; PATTERN;

D O I：

10.3109/17477166.2010.519388

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Ghrelin, released from the stomach, acts at the hypothalamus and is associated with initiation of food intake. We hypothesised that patients with craniopharyngioma and hypothalamic obesity (CRHO) would have ghrelin abnormalities. Fifteen CRHO patients and 15 BMI-matched controls underwent oral glucose tolerance test with dynamic ghrelin measurement. From 0-30 minutes, ghrelin (pg/ml) decreased less (43.4 +/- 38.8 vs. 70.8 +/- 35.8, p < 0.05) and insulin (pmol/l) increased more (1 669.2 +/- 861.7 vs. 1 049.1 +/- 560.4, p = 0.04) in CRHO compared with controls, respectively. Insulin area-under-the-curve was a weak negative predictor of the 0-30 minutes ghrelin decrease (r(2) = 0.29, p = 0.02). Delayed ghrelin suppression may contribute to obesity in CRHO.

引用

页码：285 / 288

页数：4

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