Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

被引：5
作者：
Jones, John G. [1 ]
机构：
[1] Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal
来源：
METABOLITES | 2021年 / 11卷 / 11期
关键词：
in vivo magnetic resonance; liver metabolism; hyperpolarization; stable isotopes; HEPATIC GLYCOGEN-METABOLISM; P-31 MR SPECTROSCOPY; IN-VIVO; ENERGY-METABOLISM; SKELETAL-MUSCLE; TRIGLYCERIDE CONTENT; SATURATION-TRANSFER; RELAXATION-TIMES; NMR-SPECTROSCOPY; RAT-LIVER;
D O I：
10.3390/metabo11110751
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.
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页数：15
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