Environmental Factors Associated with Altered Gut Microbiota in Children with Eczema: A Systematic Review

被引：16
作者：
Chan, Carmen W. H. [1 ]
Wong, Rosa S. [1 ]
Law, Patrick T. W. [1 ]
Wong, Cho Lee [1 ]
Tsui, Stephen K. W. [2 ]
Tang, Winnie P. Y. [1 ]
Sit, Janet W. H. [1 ]
机构：
[1] Chinese Univ Hong Kong, Nethersole Sch Nursing, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 07期
关键词：
childhood eczema; microbiome diversity; gut microbiota; allergy development; immune system; gene-environment interaction; environmental-host-microbial interaction; ATOPIC-DERMATITIS; INTESTINAL MICROBIOTA; ALLERGIC DISEASES; EARLY-LIFE; EPIDEMIOLOGY; PREVALENCE; ASTHMA; MODEL; RISK; MICE;
D O I：
10.3390/ijms17071147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eczema is a common skin condition that impairs children's daily life activities and quality of life. Previous research shows that gut microbiome composition plays an important role in the development of eczema. The present review summarizes evidence on environmental factors related to altered gut microbiota in children with eczema. We searched Medline, PubMed, Embase, and the Cochrane database of Systematic Reviews through October 2015. The search strategy focused on articles published in peer-reviewed, English-language journals with no publication year limit. Only original studies and review articles that reported environmental factors on gut microbiome specific to eczema were included in this review. We selected six studies (total 1990 participants) for full review and identified that the composition of gut microbiota specific to eczema could be influenced by the following environmental factors: length of gestation, mode of delivery, type of feeding, method of treatment, number of older siblings, and other lifestyle factors. There has been inconsistent empirical evidence as to the modulatory effects of gut microbiota on immunological functions in children with eczema. Further research on the environmental-host-microbial interaction is needed to develop a strong base of knowledge for the development and implementation of prevention strategies and policies for eczema.
引用
收藏
页数：14
相关论文
共 28 条
[1]   Gut microbiota and development of atopic eczema in 3 European birth cohorts [J].
Adlerberth, Ingegerd ;
Strachan, David P. ;
Matricardi, Paolo M. ;
Ahrne, Siv ;
Orfei, Lia ;
Aberg, Nils ;
Perkin, Michael R. ;
Tripodi, Salvatore ;
Hesselmar, Bill ;
Saalman, Robert ;
Coates, Anthony R. ;
Bonanno, Carmen L. ;
Panetta, Valentina ;
Wold, Agnes E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) :343-350
[2]   The effect of parental allergy on childhood allergic diseases depends on the sex of the child [J].
Arshad, S. Hasan ;
Karmaus, Wilfried ;
Raza, Abid ;
Kurukulaaratchy, Ramesh J. ;
Matthews, Sharon M. ;
Holloway, John W. ;
Sadeghnejad, Alireza ;
Zhang, Hongmei ;
Roberts, Graham ;
Ewart, Susan L. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (02) :427-+
[3]   Childhood atopic eczema [J].
Barnetson, RS ;
Rogers, M .
BRITISH MEDICAL JOURNAL, 2002, 324 (7350) :1376-1379
[4]   Atopic and non-atopic eczema [J].
Brown, S ;
Reynolds, NJ .
BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7541) :584-588F
[5]   New insights into the epidemiology of childhood atopic dermatitis [J].
Flohr, C. ;
Mann, J. .
ALLERGY, 2014, 69 (01) :3-16
[6]   Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infants [J].
Ismail, Intan H. ;
Oppedisano, Frances ;
Joseph, Shayne J. ;
Boyle, Robert J. ;
Licciardi, Paul V. ;
Robins-Browne, Roy M. ;
Tang, Mimi L. K. .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2012, 23 (07) :674-681
[7]   Atopic eczema/dermatitis syndrome -: a genetically complex disease.: New advances in discovering the genetic contribution [J].
Klüken, H ;
Wienker, T ;
Bieber, T .
ALLERGY, 2003, 58 (01) :5-12
[8]   Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema [J].
Lewis-Jones, S. .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2006, 60 (08) :984-992
[9]   Distinct pattern of commensal gut microbiota in toddlers with eczema [J].
Mah, K. W. ;
Bjorksten, B. ;
Lee, B. W. ;
van Bever, H. P. ;
Shek, L. P. ;
Tan, T. N. ;
Lee, Y. K. ;
Chua, K. Y. .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2006, 140 (02) :157-163
[10]   Programming infant gut microbiota: influence of dietary and environmental factors [J].
Marques, Tatiana Milena ;
Wall, Rebecca ;
Ross, R. Paul ;
Fitzgerald, Gerald F. ;
Ryan, C. Anthony ;
Stanton, Catherine .
CURRENT OPINION IN BIOTECHNOLOGY, 2010, 21 (02) :149-156
123