Long-Term Clinical Outcomes of Gastric MALT Lymphoma: A Nationwide Multicenter Study in Korea

被引：11

作者：

Kim, Joon Sung ^{[1
]}

Park, Jun Chul ^{[2
]}

Lee, Jong Yeul ^{[3
]}

Ahn, Ji Yong ^{[4
]}

Kang, Sun Hyung ^{[5
]}

Yang, Hyo-Joon ^{[6
,7
]}

Kim, Su Jin ^{[8
,9
]}

Joo, Moon Kyung ^{[10
]}

Park, Jae Myung ^{[11
]}

机构：

[1] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea

[2] Yonsei Univ, Severance Hosp, Coll Med, Div Gastroenterol, Seoul, South Korea

[3] Natl Canc Ctr, Ctr Gastr Canc, Goyang, South Korea

[4] Univ Ulsan, Asan Med Ctr, Coll Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea

[5] Chungnam Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Dajeon, South Korea

[6] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea

[7] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Gastrointestinal Canc Ctr, Seoul, South Korea

[8] Pusan Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Yangsan, South Korea

[9] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea

[10] Korea Univ, Guro Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea

[11] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

endoscopy; lymphoma; Helicobacter pylori; MALT; stomach; HELICOBACTER-PYLORI ERADICATION; MARGINAL ZONE LYMPHOMA; B-CELL LYMPHOMA; PRACTICE GUIDELINES; TISSUE LYMPHOMA; DIAGNOSIS; TRENDS;

D O I：

10.3389/fonc.2021.681689

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Treatment recommendations for gastric mucosa-associated lymphoid tissue (MALT) lymphoma are based on case series and expert opinions. Only a few previous studies have focused on the long-term outcomes of gastric MALT lymphoma, especially according to stage.</p> Methods Patients diagnosed with gastric MALT lymphoma from January 2000 to December 2018 at nine university hospitals in Korea were included. Clinical data of medical history, endoscopic features, histological diagnosis, results of Helicobacter pylori (H. pylori) testing, stage, treatment conditions, and outcomes were collected.</p> Results A total of 1,163 patients was enrolled, and 97.6% (n=1,038) of patients were diagnosed as stage IE. 10-year overall survival (OS) for the entire population was 99.1% and was better for patients in stage IE compared with patients in stage III/IV (p=0.002). The 10-year OS for H. pylori-positive patients was better than that of H. pylori-negative patients (p=0.022). Multivariate analyses revealed initial stage III/IV as a prognostic factor associated with over-all survival.</p> Conclusion The majority of gastric MALT lymphoma patients are diagnosed at an early localized stage in Korea. The overall survival rate of gastric MALT lymphoma is excellent and is associated with the initial stage of the disease.</p>

引用

页数：8

共 34 条

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