Chondrocyte Cultivationin Hyaluronan-Tyramine Cross-Linked Hydrogel

被引：5

作者：

Kucera, Lukas ^{[1
,2
]}

Weinfurterova, Radka ^{[1
]}

Dvorakova, Jana ^{[1
]}

Kucera, Jan ^{[1
,3
]}

Pravda, Martin ^{[1
]}

Foglarova, Marcela ^{[1
]}

Svik, Karol ^{[1
]}

Klein, Pavel ^{[4
]}

Velebny, Vladimir ^{[1
]}

Kubala, Lukas ^{[5
,6
]}

机构：

[1] Contipro Biotech Sro, Dolni Dobrouc, Czech Republic

[2] Masaryk Univ, Fac Sci, Dept Physiol & Immunol Anim, Inst Expt Biol, CS-61137 Brno, Czech Republic

[3] Charles Univ Prague, Dept Histol & Embryol, Med Fac Hradec Kralove, Hradec Kralove, Czech Republic

[4] Contipro Pharma As, Dolni Dobrouc, Czech Republic

[5] Acad Sci Czech Republ, Inst Biophys, CS-61265 Brno, Czech Republic

[6] St Annes Univ Hosp Brno, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, Brno, Czech Republic

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2015年 / 64卷 / 13期

关键词：

Biocompatibility; chondrogenesis; hyaluronate; scaffold; tyramine; ARTICULAR-CARTILAGE; GENE-EXPRESSION; IN-VITRO; MATRIX; DEFECTS; REPAIR; DIFFERENTIATION; CHONDROGENESIS; DEGRADATION; MODULATION;

D O I：

10.1080/00914037.2014.996715

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The application of chondrocyte-seeded hydrogels, such as tyramine-substituted hyaluronan, is a highly promising strategy for damaged cartilage treatments. The rheological characteristics of hyaluronan-tyramine derivative scaffold were determined together with the hydrogel swelling, the water uptake, and the morphological characterization. The chondrocytes seeded in hyaluronan-tyramine hydrogel were viable and expressed markers typical for differentiated chondrocytes with no signs of hypertrophy or extensive expression of matrix metalloproteinases. The lyophilized unseeded hyaluronan-tyramine scaffolds were also implantated into trochlea osteochondral defects in rabbits. In conclusion, the hyaluronan-tyramine derivative was proven to be advisable material as a scaffold for cartilage reconstitution. [GRAPHICS]

引用

页码：661 / 674

页数：14

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